Osteoarticular cells tolerate short-term exposure to nitisinone—implications in alkaptonuria
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منابع مشابه
Homogentisate 1,2 Dioxygenase is Expressed in Human Osteoarticular Cells: Implications in Alkaptonuria
Alkaptonuria (AKU) results from defective homogentisate1,2-dioxygenase (HGD), causing degenerative arthropathy. The deposition of ochronotic pigment in joints is so far attributed to homogentisic acid produced by the liver, circulating in the blood and accumulating locally. Human normal and AKU osteoarticular cells were tested for HGD gene expression by RT-PCR, mono- and 2D-Western blotting. HG...
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ژورنال
عنوان ژورنال: Clinical Rheumatology
سال: 2015
ISSN: 0770-3198,1434-9949
DOI: 10.1007/s10067-015-2983-1